Oestradiol synthesis from C19 steroids by human breast cancers
نویسندگان
چکیده
منابع مشابه
Paper chromatography of C19 steroids.
The successful use of paper chromatography for t.he separation of corticoids (2) suggested the general usefulness of this procedure for relat,ed compounds. Two procedures for t.he separation of cardiac glycosides and aglycones have been described (3, 1). Preliminary reports (5, G) and a reference (7) have been made on methods for other steroid hormones. This paper describes an effective system ...
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The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT....
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1. The amino acid L-arginine has been shown to enhance immune mechanisms and inhibit tumour growth in experimental animals, but although many of the immunological effects of arginine have been reproduced in man there have been few studies of its effects on human tumours. In this study the effects of arginine on human breast cancers were determined by measuring tumour protein synthesis and compa...
متن کاملSynthesis of 2- and 7-substituted C19 steroids having a 1,4,6-triene or 1,4-diene structure and their cytotoxic effects on T47D and MDA-MB231 breast cancer cells.
2-Chloro-, 2-bromo- and 2-azido-1,4,6-androstatriene-3,17-diones were synthesized from 1alpha,2alpha-epoxy-4,6-androstadiene-3,17-dione (2) using HCl, HBr and NaN(3), respectively. Compound 2 was also reacted with NaCN to give 2-cyano-1,4,6-androstatriene-3,17-dione (5) and 2beta-cyano-1alpha-hydroxy-4,6-androstadiene-3,17-dione (6). 6Alpha,7alpha-epoxy-1,4-androstadiene-3,17-dione (8) was reac...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1976
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1976.13